Overview
MOTS-c peptide (Mitochondrial ORF of the 12S rRNA-c) is a mitochondrial-derived peptide studied for its role in regulating energy metabolism, stress response, and exercise adaptation. Encoded by the mitochondrial genome, MOTS-c peptide is of particular interest in research focused on insulin sensitivity, AMPK activation, and cellular responses to metabolic stress. Preclinical studies suggest that MOTS-c peptide supports glucose utilization, enhances skeletal muscle endurance, and contributes to healthy aging models.
Compound Breakdown
MOTS-c (10mg): Synthetic mitochondrial peptide studied for its influence on AMPK activation, metabolic regulation, and exercise adaptation in preclinical research.
Research Applications
Preclinical investigations into MOTS-c peptide include:
Mitochondrial Function → studied for regulation of cellular energy, stress signaling, and mitochondrial biogenesis.
Metabolic Regulation → investigated for its role in insulin sensitivity, glucose metabolism, and lipid balance.
Exercise Adaptation → studied for improved skeletal muscle endurance, metabolic flexibility, and recovery under physical stress.
Longevity Pathways → explored for protection against age-related metabolic decline and oxidative stress.
Comparative Models → evaluated against other mitochondrial peptides to better understand mitochondrial-nuclear communication in metabolism.
Related Categories
MOTS-c belongs to the Longevity and Metabolic categories. Research often compares it with Tirzepatide and Semaglutide in studies of metabolic and mitochondrial pathways.
Compliance Statement
All Not Labs products are strictly for research use only and are not intended for human or veterinary use.


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