Metabolic Bundle III: Next Gen (Retatrutide + MOTS-c)

Overview

Metabolic Bundle Next Gen peptides provide researchers with a two-compound model for investigating advanced metabolic pathways, glucose regulation, and mitochondrial resilience. By combining Retatrutide, a novel triple receptor agonist, with MOTS-c, a mitochondrial-derived peptide, this bundle enables exploration of multi-pathway metabolic control and cellular energy adaptation.

Compound Breakdown

• Retatrutide (15mg) → A triple receptor agonist targeting GLP-1, GIP, and glucagon receptors. Retatrutide is studied for its ability to regulate energy expenditure, improve glucose tolerance, and support obesity and cardiometabolic research.

• MOTS-c (10mg) → A mitochondrial-encoded peptide studied for its influence on AMPK activation, cellular metabolism, and stress resistance. MOTS-c research highlights its role in insulin sensitivity, mitochondrial biogenesis, and longevity-related pathways.

Research Context

Metabolic Bundle Next Gen peptides integrate hormonal and mitochondrial pathways into one research platform:

• Retatrutide activates incretin and glucagon signaling, enabling studies of metabolic regulation and energy expenditure.

• MOTS-c modulates mitochondrial adaptation and resilience against metabolic stress.

Together, these peptides allow researchers to study overlapping endpoints such as insulin regulation, mitochondrial gene expression, inflammatory markers, and systemic metabolic flexibility in both preclinical and cellular models.

Applications

Research areas supported by Metabolic Bundle Next Gen peptides include:

• Glucose Regulation & Insulin Sensitivity → Studies of dual and triple agonist effects on glycemic control.

• Obesity & Cardiometabolic Models → Research on body weight, energy expenditure, and inflammatory biomarkers.

• Mitochondrial Adaptation → Investigations into AMPK activation, oxidative stress reduction, and energy metabolism.

• Longevity & Aging Pathways → Exploration of aging biomarkers, metabolic flexibility, and mitochondrial health.

• Comparative Studies → Evaluating dual-compound administration versus single-peptide pathways for advanced metabolic models.

Related Categories

The Metabolic Bundle III: Next Gen is part of our Bundles – Best Value collection and the Metabolic category. It combines Retatrutide and MOTS-c.

Compliance Statement

All Not Labs products are intended strictly for laboratory research use only. The Metabolic Bundle Next Gen is not approved for human or veterinary use.