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Tirzepatide Peptide (15mg / 30mg)

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Tirzepatide peptide (15mg, 30mg) — COA-verified dual GIP and GLP-1 receptor agonist studied for its effects on glucose control, metabolic regulation, and body composition pathways. High-purity, research-only compound from Not Labs.

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Overview

Tirzepatide peptide is a synthetic dual agonist of the glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. In laboratory research, it has been studied for its ability to influence glucose metabolism, insulin secretion, and body composition. By acting on two key incretin pathways, Tirzepatide peptide offers researchers a unique compound for investigating metabolic regulation, energy balance, and obesity-related biomarkers.

Compound Breakdown

Unlike single-pathway GLP-1 agonists, Tirzepatide is designed to activate both GIP and GLP-1 receptors, producing a more comprehensive incretin effect. This dual action has been associated with enhanced insulin secretion, improved glycemic control, and greater reductions in body weight in research models.

Key experimental findings include:

  • Glucose Regulation: Tirzepatide peptide enhances glucose-dependent insulin secretion in laboratory systems.

  • Appetite and Energy Balance: Research suggests potential influence on appetite signaling and energy expenditure.

  • Body Composition: Preclinical studies report reduced adiposity and improved lean mass ratios.

  • Metabolic Flexibility: Dual incretin agonism supports investigations into lipid metabolism and insulin sensitivity.

By addressing multiple metabolic pathways, Tirzepatide provides a valuable research tool for studying complex metabolic disorders.

Research Applications

Research investigations of Tirzepatide peptide have explored:

  • Metabolic Regulation: Models of glucose homeostasis, insulin sensitivity, and lipid metabolism.

  • Body Composition Studies: Assessing effects on fat mass, lean tissue, and energy utilization.

  • Obesity Research: Exploring the compound’s role in weight regulation and adipose tissue pathways.

  • Incretin Pathway Studies: Comparing dual GIP/GLP-1 agonism with single-pathway GLP-1 analogs.

  • Diabetes Research Models: Evaluating mechanisms relevant to type 2 diabetes in controlled laboratory environments.

These findings remain restricted to laboratory research and do not imply clinical outcomes.

Related Categories

Tirzepatide is part of the Metabolic category. It is often compared with Semaglutide and studied alongside MOTS-c in glucose regulation and incretin pathway research.

Compliance Statement

All Not Labs products are intended strictly for laboratory research use only. Tirzepatide peptide is not approved for human or veterinary use.

Certificate of Analysis

FAQ

1. What makes Tirzepatide peptide unique compared to other incretin compounds?
Tirzepatide is the first dual agonist of both GIP and GLP-1 receptors, providing broader incretin pathway activation than single-pathway GLP-1 analogs.

2. How is Tirzepatide studied in metabolic research?
Research focuses on glucose control, insulin secretion, lipid metabolism, and weight regulation in laboratory systems.

3. What have body composition studies shown about Tirzepatide?
Preclinical data suggest reductions in adipose tissue and improvements in lean mass, making it a key compound in obesity-related research.

4. How stable is Tirzepatide peptide in storage?
Lyophilized Tirzepatide should be stored at -20°C. After reconstitution, aliquoting and refrigeration help preserve stability for ongoing research use.

5. How does Tirzepatide differ from GLP-1–only agonists?
Tirzepatide activates both GIP and GLP-1 receptors, which may provide more comprehensive effects on metabolism and weight regulation in research models.

6. What areas beyond diabetes are researchers exploring with Tirzepatide?
Studies are expanding into obesity, cardiovascular biomarkers, and metabolic syndrome models, reflecting its broad research potential.

References

  1. Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, et al. Tirzepatide once weekly for the treatment of obesity in non-diabetic adults. N Engl J Med. 2022;387(3):205-216.
    PubMed
  2. Regmi A, et al. Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor. Cell Metabolism. 2024.
    Cell Metabolism
  3. Sattar N, et al. Tirzepatide and cardiometabolic parameters in obesity. PMC Full text. 2025.
    PMC Full text
  4. Tian Q, et al. Efficacy and safety of tirzepatide for weight loss in patients with overweight or obesity: Meta-analysis. 2025.
    PMC Full text
  5. Jastreboff AM, et al. Tirzepatide as Compared with Semaglutide for the Reduction in Body Weight and Waist Circumference at Week 72. N Engl J Med. 2025.
    NEJM

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