Metabolic Bundle I: Classic (Semaglutide + MOTS-c)

Overview

Metabolic Bundle Classic peptides provide researchers with a two-compound model for investigating glucose regulation, energy balance, and mitochondrial adaptation. By combining Semaglutide, a GLP-1 receptor agonist, with MOTS-c, a mitochondrial-derived peptide, this bundle supports research into metabolic flexibility, insulin signaling, and age-related decline in energy regulation.

Compound Breakdown

• Semaglutide (15mg) → A GLP-1 receptor agonist studied for its effects on glucose homeostasis, insulin sensitivity, and metabolic syndrome. Semaglutide has been investigated in both preclinical and clinical models for weight regulation, glycemic control, and cardiometabolic pathways.

• MOTS-c (10mg) → A mitochondrial-encoded peptide studied for its role in AMPK activation, metabolic adaptation, and cellular stress response. MOTS-c has been examined for its ability to influence insulin sensitivity, promote mitochondrial biogenesis, and improve resilience in metabolic models.

Research Context

Metabolic Bundle Classic peptides combine distinct but complementary mechanisms:

• Semaglutide modulates incretin signaling and systemic glucose regulation.

• MOTS-c enhances mitochondrial performance and cellular energy pathways.

Together, these peptides provide a comprehensive research model for metabolic health, allowing for exploration of insulin regulation, mitochondrial resilience, and overlapping endpoints such as inflammatory biomarker modulation and glucose tolerance.

Applications

Research areas supported by Metabolic Bundle Classic peptides include:

• Glucose Regulation & Insulin Sensitivity → Studies of glycemic control and endocrine pathways.

• Metabolic Syndrome Models → Investigations into obesity, insulin resistance, and cardiometabolic biomarkers.

• Mitochondrial Function & Energy Pathways → Exploration of AMPK activation, oxidative stress resistance, and mitochondrial biogenesis.

• Longevity & Aging Research → Combined peptide use supports studies of metabolic decline and aging biomarkers.

• Comparative Endocrine Studies → Evaluating dual-compound versus single-compound administration for overlapping metabolic endpoints.

Related Categories

The Metabolic Bundle I: Classic is part of our Bundles – Best Value collection and the Metabolic category. It contains Semaglutide and MOTS-c.

Compliance Statement

All Not Labs products are intended strictly for laboratory research use only. The Metabolic Bundle Classic is not approved for human or veterinary use.